At least five Islamic State jihadist fighters were killed in US airstrikes conducted Friday night in Syria, according to an announcement by the Syrian Observatory for Human Rights. The raids took place one week after the deadly attack in Palmyra, in which two American soldiers and a civilian interpreter lost their lives.
As the head of the NGO, Rami Abdel Rahman, told the French Press Agency, among the dead was “the cell leader” of ISIS in the region, responsible for drone operations, while the strikes were recorded in Deir Ezzor province in eastern Syria.
Tonight, U.S. and Jordanian forces struck 70+ ISIS targets in Syria with 100+ precision munitions. Peace through strength. pic.twitter.com/XWWvfqBBFT
— U.S. Central Command (@CENTCOM) December 20, 2025
CENTCOM forces launched fighter jets, attack helicopters and other assets to conduct the large-scale strike. pic.twitter.com/3szSo2u5rm
— U.S. Central Command (@CENTCOM) December 19, 2025
The airstrikes in Syria
The airstrikes were launched late Friday night, with the US Central Command for the Middle East (CENTCOM) announcing the start of a “massive” operation against Islamic State targets. According to American officials, it was retaliation for the attack on US personnel.
U.S. Forces Unleash Massive Strike Against ISIS in Syria
TAMPA, Fla. – U.S. forces have commenced a large-scale strike against ISIS infrastructure and weapons sites in Syria. This massive strike follows the attack on U.S. and partner forces in Syria on Dec. 13.
We will provide…
— U.S. Central Command (@CENTCOM) December 19, 2025
CENTCOM reported that US forces hit more than 70 targets in various areas of central Syria, using fighter aircraft, helicopters and artillery, while over 100 precision munitions were deployed. The operation began at 4:00 PM Washington time (11:00 PM Greek time).
— U.S. Central Command (@CENTCOM) December 20, 2025
According to Syrian security force sources, strikes occurred in the desert near Homs, as well as in provincial areas around Deir Ezzor and Raqqa. The explosions were followed by medium-caliber weapons fire in desert areas southwest of Raqqa, in zones controlled by Syria’s de facto government.
US Defense Secretary Pete Hegseth confirmed that the raids targeted “ISIS fighters, infrastructure and weapons facilities,” emphasizing that the operation was successful. “This is not the beginning of a war – it is a statement of revenge. We hunted down and killed our enemies and we will continue,” he said characteristically.
Earlier today, U.S. forces commenced OPERATION HAWKEYE STRIKE in Syria to eliminate ISIS fighters, infrastructure, and weapons sites in direct response to the attack on U.S. forces that occurred on December 13th in Palmyra, Syria.
This is not the beginning of a war — it is a…
— Secretary of War Pete Hegseth (@SecWar) December 19, 2025
Trump: “Very harsh retaliation”
Meanwhile, US President Donald Trump warned via Truth Social that “very harsh retaliation” was underway, emphasizing that the United States is hitting “Islamic State strongholds with great intensity” in Syria. In a strong tone, he conveyed that every terrorist threat against Americans will be answered “with the harshest possible force.”
It should be recalled that the Palmyra attack targeted a convoy of American and Syrian forces, with the perpetrator killed by gunfire. Syrian authorities characterized him as a member of the security forces, suspected of collaborating with the Islamic State.
In recent months, a US-led coalition, formed after Syrian President Ahmed al-Saraa’s visit to the White House, has intensified air and ground operations in Syria against ISIS suspects, often in cooperation with Syrian security forces.
According to Reuters, approximately 1,000 American soldiers remain deployed in Syria, mainly in Kurdish-controlled areas in the northeastern country, as well as at the al-Tanf base, near the border with Jordan. Donald Trump’s return to the White House has raised questions about the future of the American military presence, despite the Pentagon having announced its intention to reduce forces.